![]() Structure/function relationships in small vessels in health and disease determined by nonlinear microscopy and image-based modelling. Is microvascular function altered by glucagon-like peptide-1 in humans, in vivo? A Diabetes UK funded studentship which explores whether natural and analogues of GLP-1 are vasoactive using the local application of the agents by microinjection and assessment of perfusion with laser Doppler Perfusion imaging. Funded by TSB this project with Moor Instruments and Plastic surgeons at RD&E is testing the feasibility of the use of laser speckle in theatres to monitor perfusion in microsurgical free flaps.ĭoes dietary supplementation with nitrate enhance walking distance or exercise performance? Funded by Diabetes UK in collaboration with College of Life and Environmental Sciences, UoE, this study is using beetroot juice supplementation in patients with type 2 diabetes and COPD to assess whether the benefits seen in healthy individuals of reducing blood pressure and improving exercise efficiency translate to patients. Laser speckle imaging (LSI) – monitoring microsurgical free flaps during breast reconstruction surgery. The vascular work package in collaboration with Lund, Pisa, Dundee and Florence explores novel techniques to assess plaque structure, microvascular function and assess the use of optical coherence tomography to detect early changes in retinal thickness in patients with diabetes with and without cardiovascular disease. ![]() ![]() Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT-IMI).
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